Jump to main content
Jump to site search

Issue 49, 2021
Previous Article Next Article

Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies

Author affiliations

Abstract

SARS-CoV-2 VOC immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOCs is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. The P.3 variant is a putative VOC.

Graphical abstract: Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies

Back to tab navigation

Supplementary files

Article information


Submitted
01 Apr 2021
Accepted
14 May 2021
First published
14 May 2021

Chem. Commun., 2021,57, 6094-6097
Article type
Communication

Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies

M. V. F. Ferraz, E. G. Moreira, D. F. Coêlho, G. L. Wallau and R. D. Lins, Chem. Commun., 2021, 57, 6094 DOI: 10.1039/D1CC01747K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements