Jump to main content
Jump to site search

Issue 38, 2021
Previous Article Next Article

Platinum complexes act as shielding agents against virus infection

Author affiliations

Abstract

We determine that the substitution-inert polynuclear platinum complex (PPC) TriplatinNC is an antiviral agent and protects cells from enterovirus 71 and human metapneumovirus infection. This protection occurs through the formation of adducts with cell–surface glycosaminoglycans. Our detailed mechanistic investigation demonstrates that TriplatinNC blocks viral entry by shielding cells from virus attack, opening new directions for metalloshielding antiviral drug development.

Graphical abstract: Platinum complexes act as shielding agents against virus infection

Back to tab navigation

Supplementary files

Article information


Submitted
24 Mar 2021
Accepted
04 Apr 2021
First published
06 Apr 2021

Chem. Commun., 2021,57, 4666-4669
Article type
Communication

Platinum complexes act as shielding agents against virus infection

B. Bailly, A. K. Gorle, L. Dirr, A. K. Malde, N. P. Farrell, S. J. Berners-Price and M. von Itzstein, Chem. Commun., 2021, 57, 4666
DOI: 10.1039/D1CC01593A

Social activity

Search articles by author

Spotlight

Advertisements