Lianguo Chen, Hong-jian Wang, Teng-fei Ji and Chong-Jing Zhang
Chem. Commun., 2021,57, 5981-5984
DOI:
10.1039/D1CC01522B,
Communication
Although sinomenine (SIN) has been used to treat several inflammation-related diseases in the clinic for decades, the detailed anti-inflammatory mechanism remains elusive. Here, we present a chemoproteomic study that supports a polypharmacological mode of action for SIN to inhibit inflammation. Notably, functional validation revealed multiple new protein regulators whose knockdown could significantly affect inflammation.
