Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C–carbonyls

Abstract

A direct CO₂-fixation methodology couples structurally diverse iminophosphoranes with various nucleophiles to synthesize ureas, carbamates, thiocarbamates, and amides, and is amenable for ¹¹C radiolabeling. This methodology is practical, as demonstrated by the synthesis of >35 products and isolation of the molecular imaging radiopharmaceuticals [¹¹C]URB694 and [¹¹C]glibenclamide.