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Issue 28, 2021
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Aptamer-based proximity labeling guides covalent RNA modification

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Abstract

We describe the development of a proximity-induced bio-orthogonal inverse electron demand Diels–Alder reaction that exploits the high-affinity interaction between a dienophile-modified RhoBAST aptamer and its tetramethyl rhodamine methyltetrazine substrate. We applied this concept for covalent RNA labeling in proof-of-principle experiments.

Graphical abstract: Aptamer-based proximity labeling guides covalent RNA modification

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Article information


Submitted
16 Feb 2021
Accepted
04 Mar 2021
First published
04 Mar 2021

Chem. Commun., 2021,57, 3480-3483
Article type
Communication

Aptamer-based proximity labeling guides covalent RNA modification

D. Englert, R. Matveeva, M. Sunbul, R. Wombacher and A. Jäschke, Chem. Commun., 2021, 57, 3480
DOI: 10.1039/D1CC00786F

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