Jump to main content
Jump to site search

Issue 28, 2021
Previous Article Next Article

Aptamer-based proximity labeling guides covalent RNA modification

Author affiliations

Abstract

We describe the development of a proximity-induced bio-orthogonal inverse electron demand Diels–Alder reaction that exploits the high-affinity interaction between a dienophile-modified RhoBAST aptamer and its tetramethyl rhodamine methyltetrazine substrate. We applied this concept for covalent RNA labeling in proof-of-principle experiments.

Graphical abstract: Aptamer-based proximity labeling guides covalent RNA modification

Back to tab navigation

Supplementary files

Article information


Submitted
16 Feb 2021
Accepted
04 Mar 2021
First published
04 Mar 2021

Chem. Commun., 2021,57, 3480-3483
Article type
Communication

Aptamer-based proximity labeling guides covalent RNA modification

D. Englert, R. Matveeva, M. Sunbul, R. Wombacher and A. Jäschke, Chem. Commun., 2021, 57, 3480 DOI: 10.1039/D1CC00786F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements