A porphysome-based photodynamic O2 economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration

Rongrong Zheng‡; Xiayun Chen‡; Linping Zhao; Ni Yang; Runtian Guan; Ali Chen; Xiyong Yu; Hong Cheng; Chang Wang; Shiying Li

doi:10.1039/D1CC00544H

A porphysome-based photodynamic O₂ economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration†

Rongrong Zheng‡,^a Xiayun Chen‡,‡^a Linping Zhao,^a Ni Yang,^a Runtian Guan,^a Ali Chen,^a Xiyong Yu,^a Hong Cheng,

*^b Chang Wang*^a and Shiying Li

*^a

Author affiliations

* Corresponding authors

^a Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, P. R. China
E-mail: lisy-sci@gzhmu.edu.cn, wangchang047@hotmail.com

^b Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, P. R. China
E-mail: chengh@smu.edu.cn

Abstract

A porphysome-based photodynamic O₂ economizer (P-PAT) is prepared for hypoxic tumor therapy. The self-assembled porphyrin bilayers of P-PAT possess high loading capacity to atovaquone (ATO) (nearly 70%), which could restrain mitochondrial respiration to relieve hypoxia and enhance photodynamic therapy.

Chemical Communications

A porphysome-based photodynamic O₂ economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration†

Abstract

Supplementary files

Article information

Download Citation

Permissions

A porphysome-based photodynamic O₂ economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration

Social activity

Search articles by author

Spotlight

Advertisements

Chemical Communications