Jump to main content
Jump to site search


C2-Selective silylation of pyridines by a rhodium–aluminum complex

Author affiliations

Abstract

We have developed a C2-selective mono-silylation of a variety of pyridines using a Rh–Al complex. Both the site- and mono-selectivity are controlled via the pyridine coordination to the Lewis-acidic Al center prior to the activation of the pyridine C(2)–H bond at the proximal Rh center. A reaction mechanism is proposed based on several mechanistic studies, including the isolation of a (2-pyridyl)silylrhodium intermediate.

Graphical abstract: C2-Selective silylation of pyridines by a rhodium–aluminum complex

Back to tab navigation

Supplementary files

Article information


Submitted
16 Jan 2021
Accepted
04 May 2021
First published
04 May 2021

Chem. Commun., 2021, Advance Article
Article type
Communication

C2-Selective silylation of pyridines by a rhodium–aluminum complex

N. Hara, N. Uemura and Y. Nakao, Chem. Commun., 2021, Advance Article , DOI: 10.1039/D1CC00278C

Social activity

Search articles by author

Spotlight

Advertisements