Issue 23, 2021

A bioinspired oxoiron(iv) motif supported on a N2S2 macrocyclic ligand

Abstract

A mononuclear oxoiron(IV) complex 1-trans bearing two equatorial sulfur ligations is synthesized and characterized as an active-site model of the elusive sulfur-ligated FeIV[double bond, length as m-dash]O intermediates in non-heme iron oxygenases. The introduction of sulfur ligands weakens the Fe[double bond, length as m-dash]O bond and enhances the oxidative reactivity of the FeIV[double bond, length as m-dash]O unit with a diminished deuterium kinetic isotope effect, thereby providing a compelling rationale for nature's use of the cis-thiolate ligated oxoiron(IV) motif in key metabolic transformations.

Graphical abstract: A bioinspired oxoiron(iv) motif supported on a N2S2 macrocyclic ligand

Supplementary files

Article information

Article type
Communication
Submitted
14 Jan 2021
Accepted
17 Feb 2021
First published
17 Feb 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2021,57, 2947-2950

A bioinspired oxoiron(IV) motif supported on a N2S2 macrocyclic ligand

J. Deutscher, P. Gerschel, K. Warm, U. Kuhlmann, S. Mebs, M. Haumann, H. Dau, P. Hildebrandt, U. Apfel and K. Ray, Chem. Commun., 2021, 57, 2947 DOI: 10.1039/D1CC00250C

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