Issue 23, 2021
From the journal:

Chemical Communications

pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation†

Tomomi Koshiyama, ORCID logo *a   Yuki Inoue,b   Sana Asada,b   Koki Kawahara,b   Shogo Ide,b   Kazuma Yasuharac  and  Masaaki Ohba ORCID logo *b  

* Corresponding authors

a Department of Applied Chemistry, College of Life Sciences, Ritsumeikan University, 1-1-1, Noji-higashi, Kusatsu, Shiga 525-8577, Japan
E-mail: koshi@fc.ritsumei.ac.jp

b Department of Chemistry, Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
E-mail: ohba@chem.kyushu-univ.jp

c Division of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, Japan

Abstract

Amphotericin B incorporating 2,2′-bipyridine (bpy-AmB) forms a membrane channel exhibiting pH-dependent Ca2+ ion permeability with a selective response to Cu2+ ions. The coordination structure at bpy sites depends on the pH and metal ions can control the association state of bpy-AmB in the membrane.

Graphical abstract: pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation

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Article information

DOI
https://doi.org/10.1039/D0CC08368B
Article type
Communication
Submitted
27 Dec 2020
Accepted
04 Feb 2021
First published
09 Feb 2021

Chem. Commun., 2021,57, 2895-2898

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pH-Dependent ion permeability control of a modified amphotericin B channel through metal complexation

T. Koshiyama, Y. Inoue, S. Asada, K. Kawahara, S. Ide, K. Yasuhara and M. Ohba, Chem. Commun., 2021, 57, 2895 DOI: 10.1039/D0CC08368B

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