Issue 24, 2021

The proximity of the G-quadruplex to hemin impacts the intrinsic DNAzyme activity in mitochondria

Abstract

The DNAzyme activity of G-quadruplex/hemin in mitochondria has not been characterized. Herein, we report an unexpected difference in the DNAzyme activity between IN VITRO assays and in mitochondria. Molecular dynamic simulations illustrate how the interaction of the G-quadruplex with hemin may modulate the DNAzyme activity. These results might facilitate a better understanding of the catalytic mechanism of the DNAzyme and help the rational design of stable and active DNAzymes suitable for intracellular catalysis.

Graphical abstract: The proximity of the G-quadruplex to hemin impacts the intrinsic DNAzyme activity in mitochondria

Supplementary files

Article information

Article type
Communication
Submitted
23 Dec 2020
Accepted
09 Feb 2021
First published
09 Feb 2021

Chem. Commun., 2021,57, 3038-3041

The proximity of the G-quadruplex to hemin impacts the intrinsic DNAzyme activity in mitochondria

J. Zhang, X. Song, M. Xia, Y. Xue, M. Zhou, L. Ruan, H. Lu, J. Chen, D. Wang, Z. Chai and Y. Hu, Chem. Commun., 2021, 57, 3038 DOI: 10.1039/D0CC08316J

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