Photoactivated release of membrane impermeant sulfonates inside cells†
Stuart T.
Caldwell, 
a
Sean N.
O'Byrne,
a
Calum
Wilson,
b
Michael P.
Murphy,
c
John G.
McCarron
b
and
Richard C.
Hartley
*a
a
Sean N.
O'Byrne,
a
Calum
Wilson,
b
Michael P.
Murphy,
c
John G.
McCarron
b
and
Richard C.
Hartley
*a
Abstract
Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell.
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