Issue 12, 2021

Ag-Catalyzed ring-opening of tertiary cycloalkanols for C–H functionalization of cyclic aldimines

Abstract

We firstly describe a silver-catalyzed direct C–H functionalization of cyclic aldimines with cyclopropanols and cyclobutanols via a radical-mediated C–C bond cleavage strategy. The desired products were generated in decent yields with wide substrate scope under mild reaction conditions. In addition, a gram-scale reaction and synthetic transformation of the product were performed.

Graphical abstract: Ag-Catalyzed ring-opening of tertiary cycloalkanols for C–H functionalization of cyclic aldimines

Supplementary files

Article information

Article type
Communication
Submitted
01 Nov 2020
Accepted
04 Jan 2021
First published
04 Jan 2021

Chem. Commun., 2021,57, 1506-1509

Ag-Catalyzed ring-opening of tertiary cycloalkanols for C–H functionalization of cyclic aldimines

J. Wang, X. Liu, Z. Wu, F. Li, M. Zhang, Y. Mi, J. Wei, Y. Zhou and L. Liu, Chem. Commun., 2021, 57, 1506 DOI: 10.1039/D0CC07181A

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