Issue 12, 2021
From the journal:

Chemical Communications

Non-genetic cell-surface modification with a self-assembling molecular glue†

Hayase Hakariya, ORCID logo abc   Ippei Takashima, ORCID logo a   Misao Takemoto,a   Naotaka Noda,ab   Shin-ichi Sato ORCID logo a  and  Motonari Uesugi ORCID logo *ade  

* Corresponding authors

a Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan
E-mail: uesugi@scl.kyoto-u.ac.jp

b Graduate School of Medicine, Kyoto University, Uji, Kyoto 611-0011, Japan

c Training Program of Leaders for Integrated Medical System (LIMS), Kyoto University, Sakyo-ku, Kyoto, Japan

d Institute for Integrated Cell-Materials Sciences (WPI-iCeMS), Kyoto University, Uji, Kyoto 611-0011, Japan

e School of Pharmacy, Fudan University, Shanghai 201203, China

Abstract

This report describes the development of a non-genetic cell-surface modification method, in which a self-assembling small molecule is combined with Halo-tag proteins. Cell-surface functionalization with cancer-linked extracellular proteins led to enhanced cell motility, angiogenesis, and immune shielding of the cells, paving the way for translational opportunities for cell therapy.

Graphical abstract: Non-genetic cell-surface modification with a self-assembling molecular glue

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Article information

DOI
https://doi.org/10.1039/D0CC07171D
Article type
Communication
Submitted
29 Oct 2020
Accepted
04 Jan 2021
First published
05 Jan 2021

Chem. Commun., 2021,57, 1470-1473

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Non-genetic cell-surface modification with a self-assembling molecular glue

H. Hakariya, I. Takashima, M. Takemoto, N. Noda, S. Sato and M. Uesugi, Chem. Commun., 2021, 57, 1470 DOI: 10.1039/D0CC07171D

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