Guanosine-rich aptamers@Cu2O nanoparticles: enhanced peroxidase activity and specific recognition capability at neutral pH

Hongchao Ma; Lan Wang; Yifan Li; Yanhui Wei

doi:10.1039/D0CC06877B

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Guanosine-rich aptamers@Cu₂O nanoparticles: enhanced peroxidase activity and specific recognition capability at neutral pH†

Hongchao Ma,

*^a Lan Wang,^a Yifan Li

^a and Yanhui Wei*^b

Author affiliations

* Corresponding authors

^a State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, China
E-mail: mahc@upc.edu.cn

^b College of Chemistry and Material Science, Shandong Agricultural University, Taian, Shandong, P. R. China
E-mail: yhwei@sdau.edu.cn

Abstract

The decoration of Cu₂O nanoparticles with guanosine-rich aptamers can significantly enhance their peroxidase activity at neutral pH and endow them with specific recognition capabilities. Both the phosphate backbone and guanine of the aptamers contribute to the enhancement. The excellent enzyme-like properties of this Cu₂O–aptamer system make it a versatile platform for the development of neutral pH biosensors.

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Article information

DOI: https://doi.org/10.1039/D0CC06877B
Article type: Communication
Submitted: 15 Oct 2020
Accepted: 01 Dec 2020
First published: 09 Dec 2020

Download Citation

Chem. Commun., 2021,57, 643-646

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Guanosine-rich aptamers@Cu₂O nanoparticles: enhanced peroxidase activity and specific recognition capability at neutral pH

H. Ma, L. Wang, Y. Li and Y. Wei, Chem. Commun., 2021, 57, 643 DOI: 10.1039/D0CC06877B

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