Issue 9, 2021
From the journal:

Chemical Communications

Dual recognition element-controlled logic DNA circuit for COVID-19 detection based on exonuclease III and DNAzyme†

Jiafeng Pan,a   Ying He,a   Zhi Liu*a  and  Junhua Chen ORCID logo *b  

* Corresponding authors

a College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China
E-mail: tigerzhiliu@126.com

b National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, China
E-mail: 222chenjunhua@163.com, jhchen@soil.gd.cn

Abstract

Two fragments of the COVID-19 genome (specific and homologous) were used as two inputs to construct an AND logic gate for COVID-19 detection based on exonuclease III and DNAzyme. The detection sensitivity of the assay can reach fM levels. Satisfactory recovery values were obtained in real sample analysis.

Graphical abstract: Dual recognition element-controlled logic DNA circuit for COVID-19 detection based on exonuclease III and DNAzyme

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Article information

DOI
https://doi.org/10.1039/D0CC06799G
Article type
Communication
Submitted
12 Oct 2020
Accepted
18 Dec 2020
First published
18 Dec 2020

Chem. Commun., 2021,57, 1125-1128

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Dual recognition element-controlled logic DNA circuit for COVID-19 detection based on exonuclease III and DNAzyme

J. Pan, Y. He, Z. Liu and J. Chen, Chem. Commun., 2021, 57, 1125 DOI: 10.1039/D0CC06799G

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