Issue 5, 2021

Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

Abstract

The investigation of microbiome-derived metabolites is important to understand metabolic interactions with their human host. New methodologies for mass spectrometric discovery of undetected metabolites with unknown bioactivity are required. Herein, we introduce squaric acid as a new chemoselective moiety for amine metabolite analysis in human fecal samples.

Graphical abstract: Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

Supplementary files

Article information

Article type
Communication
Submitted
15 Jun 2021
Accepted
10 Aug 2021
First published
12 Aug 2021
This article is Open Access
Creative Commons BY-NC license

RSC Chem. Biol., 2021,2, 1479-1483

Squaric acid as a new chemoselective moiety for mass spectrometry-based metabolomics analysis of amines

W. Lin, Z. Yang, A. Kaur, A. Block, M. Vujasinovic, J.-Matthias Löhr and D. Globisch, RSC Chem. Biol., 2021, 2, 1479 DOI: 10.1039/D1CB00132A

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