Issue 4, 2021

Interfacing non-enzymatic catalysis with living microorganisms


Interfacing non-enzymatic catalysis with cellular metabolism is emerging as a powerful approach to produce a range of high value small molecules and polymers. In this review, we highlight recent examples from this promising young field. Specifically, we discuss demonstrations of living cells mediating redox processes for biopolymer production, interfacing solar-light driven chemistry with microbial metabolism, and intra- and extracellular non-enzymatic catalysis to generate high value molecules. This review highlights the vast potential of this nascent field to bridge the two disciplines of synthetic chemistry and synthetic biology for a sustainable chemical industry.

Graphical abstract: Interfacing non-enzymatic catalysis with living microorganisms

Article information

Article type
Review Article
01 Apr 2021
27 May 2021
First published
04 Jun 2021
This article is Open Access
Creative Commons BY license

RSC Chem. Biol., 2021,2, 1073-1083

Interfacing non-enzymatic catalysis with living microorganisms

J. C. Sadler, J. A. Dennis, N. W. Johnson and S. Wallace, RSC Chem. Biol., 2021, 2, 1073 DOI: 10.1039/D1CB00072A

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