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Issue 6, 2021
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The self-assembly of a hybrid photosensitizer for the synergistically enhanced photodynamic/photothermal therapy

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Abstract

The simultaneous near-infrared (NIR)-absorbed photodynamic therapy (PDT)/photothermal therapy (PTT) has proved to be a promising approach to increase the antitumor efficiency due to their synergistic effect. Herein, a boron dipyrromethene (BODIPY)-based photosensitizer was designed and synthesized for the enhanced synergistic NIR-absorbed PDT/PTT therapy upon NIR light irradiation. In this strategy, a three-dimensional rigid polyhedral oligomeric silsesquioxane (POSS) block was introduced into the Br-BODIPY molecule to alleviate the aggregation of the photosensitizer. The POSS hybrid BODIPY (Br-BODIPY-POSS) was further functionalized with a biocompatible amphiphilic PEG via a facile thiol–ene “click” reaction, affording Br-BODIPY-POSS-PEG2000 (BBPP). BBPP can self-assemble into nanoparticles, which maintain a competitive photothermal conversion efficiency (ηBBPP = 30.2%) with its counterpart Br-BODIPY-PEG (BBP, ηBBP = 34.5%). Significantly, BBPP exhibited a relatively higher oxygen quantum yield (ΦBBPP = 0.405) than BBP (ΦBBP = 0.175). The in vitro and in vivo experiments showed that BBPP possessed negligible dark cytotoxicity and a better phototherapeutic outcome than BBP. The proof-of-concept of the POSS hybrid photosensitizer offers guidance for the construction of single-component and PDT/PTT-balanced NIR nanoagents to promote the cancer therapeutic efficacy in the future.

Graphical abstract: The self-assembly of a hybrid photosensitizer for the synergistically enhanced photodynamic/photothermal therapy

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Supplementary files

Article information


Submitted
04 Nov 2020
Accepted
17 Dec 2020
First published
04 Jan 2021

Biomater. Sci., 2021,9, 2115-2123
Article type
Paper

The self-assembly of a hybrid photosensitizer for the synergistically enhanced photodynamic/photothermal therapy

J. Chen, Y. Cui, K. Song, T. Liu, L. Zhou, B. Bao, R. Wang and L. Wang, Biomater. Sci., 2021, 9, 2115
DOI: 10.1039/D0BM01863E

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