Issue 4, 2021
From the journal:

Biomaterials Science

Targeted nanoscale therapeutics for myocardial infarction

Holly L. Sullivan,a   Nathan C. Gianneschi ORCID logo *b  and  Karen L. Christman ORCID logo *a  

* Corresponding authors

a Department of Bioengineering and Sanford Consortium for Regenerative, Medicine, University of California, San Diego, La Jolla, USA
E-mail: christman@eng.ucsd.edu

b Department of Chemistry, Department of Materials Science and Engineering, Department of Biomedical Engineering, Department of Pharmacology, International Institute for Nanotechnology, Simpson Querrey Institute, Chemistry of Life Processes Institute, Lurie Cancer Center, Northwestern University, Evanston, IL, USA

Abstract

Nanoscale therapeutics have promise for the administration of therapeutic small molecules and biologics to the heart following myocardial infarction. Directed delivery to the infarcted region of the heart using minimally invasive routes is critical to this promise. In this review, we will discuss the advances and design considerations for two nanoscale therapeutics engineered to target the infarcted heart, nanoparticles and adeno-associated viruses.

Graphical abstract: Targeted nanoscale therapeutics for myocardial infarction

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Article information

DOI
https://doi.org/10.1039/D0BM01677B
Article type
Review Article
Submitted
01 Oct 2020
Accepted
03 Dec 2020
First published
16 Dec 2020

Biomater. Sci., 2021,9, 1204-1216

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Targeted nanoscale therapeutics for myocardial infarction

H. L. Sullivan, N. C. Gianneschi and K. L. Christman, Biomater. Sci., 2021, 9, 1204 DOI: 10.1039/D0BM01677B

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