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Issue 24, 2021

Skin protein-derived peptide-conjugated vesicular nanocargos for selected skin cell targeting and consequent activation

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Abstract

Several studies have reported that a drug nanocarrier conjugated with ligands having cell binding ability improves drug delivery performance, but multiple cell-targeting and the resultant activation in designated cells has not been investigated yet. This study reports a skin cell multi-targeting vesicular nanocargo system. We selectively conjugated several skin protein-derived cell-targeting peptides (CTPs), including KTTKS, NAP-amide, and Lam332, to amphiphilic polymer-reinforced lipid nanovesicles (PLNVs) to specifically target fibroblasts, melanocytes, and keratinocytes, respectively, through effective association with the corresponding cell membrane receptors. We then showed that CTP-conjugated PLNVs specifically bind to the designated skin cells, even in a mixture of different types of skin cells, eventually leading to skin cell multi-targeting and consequent activation. These results highlight that this CTP-conjugated PLNV system has significant potential for developing an intelligent cellular drug delivery technology for dermatological applications.

Graphical abstract: Skin protein-derived peptide-conjugated vesicular nanocargos for selected skin cell targeting and consequent activation

Supplementary files

Article information


Submitted
26 Apr 2021
Accepted
31 May 2021
First published
02 Jun 2021

J. Mater. Chem. B, 2021,9, 4956-4962
Article type
Paper

Skin protein-derived peptide-conjugated vesicular nanocargos for selected skin cell targeting and consequent activation

J. H. Cho, J. Y. Kang, S. Kim, H. R. Baek, J. Kim, K. Jang and J. W. Kim, J. Mater. Chem. B, 2021, 9, 4956 DOI: 10.1039/D1TB00935D

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