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Issue 2, 2021
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Pre-targeting with ultra-small nanoparticles: boron carbon dots as drug candidates for boron neutron capture therapy

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Abstract

Boron neutron capture therapy (BNCT) is a promising cancer treatment exploiting the neutron capture capacity and subsequent fission reaction of boron-10. The emergence of nanotechnology has encouraged the development of nanocarriers capable of accumulating boron atoms preferentially in tumour cells. However, a long circulation time, required for high tumour accumulation, is usually accompanied by accumulation of the nanosystem in organs such as the liver and the spleen, which may cause off-target side effects. This could be overcome by using small-sized boron carriers via a pre-targeting strategy. Here, we report the preparation, characterisation and in vivo evaluation of tetrazine-functionalised boron-rich carbon dots, which show very fast clearance and low tumour uptake after intravenous administration in a mouse HER2 (human epidermal growth factor receptor 2)-positive tumour model. Enhanced tumour accumulation was achieved when using a pretargeting approach, which was accomplished by a highly selective biorthogonal reaction at the tumour site with trans-cyclooctene-functionalised Trastuzumab.

Graphical abstract: Pre-targeting with ultra-small nanoparticles: boron carbon dots as drug candidates for boron neutron capture therapy

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Article information


Submitted
03 Aug 2020
Accepted
18 Nov 2020
First published
18 Nov 2020

J. Mater. Chem. B, 2021,9, 410-420
Article type
Paper

Pre-targeting with ultra-small nanoparticles: boron carbon dots as drug candidates for boron neutron capture therapy

I. V. J. Feiner, K. R. Pulagam, K. B. Uribe, R. Passannante, C. Simó, K. Zamacola, V. Gómez-Vallejo, N. Herrero-Álvarez, U. Cossío, Z. Baz, M. M. Caffarel, C. H. Lawrie, D. J. Vugts, L. Rejc and J. Llop, J. Mater. Chem. B, 2021, 9, 410
DOI: 10.1039/D0TB01880E

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