Implementing Zn2+ ion and pH-value control into artificial mussel glue proteins by abstracting a His-rich domain from preCollagen

Sandra Arias; Shahrouz Amini; Jana M. Krüger; Lukas D. Bangert; Hans G. Börner

doi:10.1039/D0SM02118K

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Implementing Zn²⁺ ion and pH-value control into artificial mussel glue proteins by abstracting a His-rich domain from preCollagen†

Sandra Arias,

^a Shahrouz Amini,

^b Jana M. Krüger,^a Lukas D. Bangert

^a and Hans G. Börner

*^a

Author affiliations

* Corresponding authors

^a Humboldt-Universität zu Berlin, Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Brook-Taylor-Str. 2, Berlin D-12489, Germany
E-mail: h.boerner@HU-Berlin.de

^b Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, Potsdam 14424, Germany

Abstract

A His-rich domain of preCollagen-D found in byssal threads is derivatized with Cys and Dopa flanks to allow for mussel-inspired polymerization. Artificial mussel glue proteins are accessed that combine cysteinyldopa for adhesion with sequences for pH or Zn²⁺ induced β-sheet formation. The artificial constructs show strong adsorption to Al₂O₃, the resulting coatings tolerate hypersaline conditions and cohesion is improved by activating the β-sheet formation, that enhances E-modulus up to 60%.

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Article information

DOI: https://doi.org/10.1039/D0SM02118K
Article type: Communication
Submitted: 27 Nov 2020
Accepted: 04 Feb 2021
First published: 05 Feb 2021
This article is Open Access

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Soft Matter, 2021,17, 2028-2033

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Implementing Zn²⁺ ion and pH-value control into artificial mussel glue proteins by abstracting a His-rich domain from preCollagen

S. Arias, S. Amini, J. M. Krüger, L. D. Bangert and H. G. Börner, Soft Matter, 2021, 17, 2028 DOI: 10.1039/D0SM02118K

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