Issue 42, 2021

Origin of enantioselectivity reversal in Lewis acid-catalysed Michael additions relying on the same chiral source

Abstract

Enantiodivergence is an important concept in asymmetric catalysis that enables access to both enantiomers of a product relying on the same chiral source as reagent. This strategy is particularly appealing as an alternate approach when only one enantiomer of the required chiral ligand is readily accessible but both enantiomers of the product are desired. Despite the potential significance, general catalytic methods to effectively reverse enantioselectivity by changing an achiral reaction parameter remain underdeveloped. Herein we report our studies focused on elucidating the origin of metal-controlled enantioselectivity reversal in Lewis acid-catalysed Michael additions. Rigorous experimental and computational investigations reveal that specific Lewis and Brønsted acid interactions between the substrate and ligand change depending on the ionic radius of the metal catalyst, and are key factors responsible for the observed enantiodivergence. This holds potential to further our understanding of and facilitate the design of future enantiodivergent transformations.

Graphical abstract: Origin of enantioselectivity reversal in Lewis acid-catalysed Michael additions relying on the same chiral source

Supplementary files

Article information

Article type
Edge Article
Submitted
08 Jul 2021
Accepted
04 Oct 2021
First published
04 Oct 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2021,12, 14133-14142

Origin of enantioselectivity reversal in Lewis acid-catalysed Michael additions relying on the same chiral source

P. S. Riehl, A. D. Richardson, T. Sakamoto, J. P. Reid and C. S. Schindler, Chem. Sci., 2021, 12, 14133 DOI: 10.1039/D1SC03741B

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