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Issue 20, 2021

An integrated console for capsule-based, automated organic synthesis

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Abstract

The current laboratory practices of organic synthesis are labor intensive, impose safety and environmental hazards, and hamper the implementation of artificial intelligence guided drug discovery. Using a combination of reagent design, hardware engineering, and a simple operating system we provide an instrument capable of executing complex organic reactions with prepacked capsules. The machine conducts coupling reactions and delivers the purified products with minimal user involvement. Two desirable reaction classes – the synthesis of saturated N-heterocycles and reductive amination – were implemented, along with multi-step sequences that provide drug-like organic molecules in a fully automated manner. We envision that this system will serve as a console for developers to provide synthetic methods as integrated, user-friendly packages for conducting organic synthesis in a safe and convenient fashion.

Graphical abstract: An integrated console for capsule-based, automated organic synthesis

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Article information


Submitted
22 Feb 2021
Accepted
09 Apr 2021
First published
13 Apr 2021

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2021,12, 6977-6982
Article type
Edge Article

An integrated console for capsule-based, automated organic synthesis

T. Jiang, S. Bordi, A. E. McMillan, K. Chen, F. Saito, P. L. Nichols, B. M. Wanner and J. W. Bode, Chem. Sci., 2021, 12, 6977 DOI: 10.1039/D1SC01048D

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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