Issue 17, 2021

In vivo oral insulin delivery via covalent organic frameworks


With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids in vitro as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in vivo in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.

Graphical abstract: In vivo oral insulin delivery via covalent organic frameworks

Supplementary files

Article information

Article type
Edge Article
27 Sep 2020
03 Mar 2021
First published
06 Apr 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2021,12, 6037-6047

In vivo oral insulin delivery via covalent organic frameworks

F. Benyettou, N. Kaddour, T. Prakasam, G. Das, S. K. Sharma, S. A. Thomas, F. Bekhti-Sari, J. Whelan, M. A. Alkhalifah, M. Khair, H. Traboulsi, R. Pasricha, R. Jagannathan, N. Mokhtari-Soulimane, F. Gándara and A. Trabolsi, Chem. Sci., 2021, 12, 6037 DOI: 10.1039/D0SC05328G

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