Jump to main content
Jump to site search

Issue 2, 2021

Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines

Author affiliations

Abstract

Current drug production in batch cannot adapt rapidly to market demands, evidenced by recent shortages in many markets globally of essential medicines. Flow chemistry is a valuable tool for on-demand production of active pharmaceutical ingredients (APIs). Here, we reveal a new concept to develop and produce APIs, where an automated synthesizer that works with discrete volumes of solutions is employed at the discovery stage to identify the optimal synthetic route and conditions before a commercially available continuous flow system is used for scale-up. This concept is illustrated by the synthesis of nifedipine and paracetamol, in short supply in Germany during the COVID-19 pandemic, and the local anesthetic lidocaine.

Graphical abstract: Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines

Supplementary files

Article information


Submitted
25 Nov 2020
Accepted
05 Jan 2021
First published
05 Jan 2021

This article is Open Access

React. Chem. Eng., 2021,6, 220-224
Article type
Communication

Combining radial and continuous flow synthesis to optimize and scale-up the production of medicines

M. Guidi, S. Moon, L. Anghileri, D. Cambié, P. H. Seeberger and K. Gilmore, React. Chem. Eng., 2021, 6, 220 DOI: 10.1039/D0RE00445F

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements