Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine†
Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.
- This article is part of the themed collection: 2021 RSC Advances HOT Article Collection