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Issue 1, 2021
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Vesicular systems for dermal and transdermal drug delivery

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Abstract

Dermal/transdermal drug delivery continues to grow in importance as a means of enhancing treatment activity while reducing toxicity by avoiding the systemic absorption of the drug. At the same time, this has led to the adjustment of a wide diversity of drug carriers. This paper begins with a review of the skin, including its structure and the parameters that influence drug diffusion, followed by strategies to improve dermal drug delivery. Of the multitude of existing carriers, we will focus on the most advanced vectors in dermal/transdermal delivery, and in particular, on vesicular systems. This review will present the state of the art as well as the new trends in this domain. Through the description of these systems, we will try to obtain information on the ideal properties that the carrier must have in order to improve the cutaneous and transcutaneous penetration of the drug.

Graphical abstract: Vesicular systems for dermal and transdermal drug delivery

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Article information


Submitted
10 Nov 2020
Accepted
12 Dec 2020
First published
23 Dec 2020

This article is Open Access

RSC Adv., 2021,11, 442-451
Article type
Review Article

Vesicular systems for dermal and transdermal drug delivery

C. Richard, S. Cassel and M. Blanzat, RSC Adv., 2021, 11, 442
DOI: 10.1039/D0RA09561C

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material and it is not used for commercial purposes.

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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
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    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
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    [Original citation] - Published by The Royal Society of Chemistry.

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