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Issue 14, 2021
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Polymers and boron neutron capture therapy (BNCT): a potent combination

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Abstract

Boron neutron capture therapy (BNCT) has a long history of unfulfilled promises for the treatment of aggressive cancers. In the last two decades, chemists, physicists, and clinical scientists have been coordinating their efforts to overcome practical and scientific challenges needed to unlock its full therapeutic potential. From a chemistry point of view, the two current small-molecule drugs used in the clinic were developed in the 1950s, however, they both lack some of the essential requirements for making BNCT a successful therapeutic modality. Novel strategies are currently used to design new drugs, more selective towards cancer cells and tumours, as well as able to deliver high boron contents to the target. In this context, macromolecules, including polymers, are promising tools to make BNCT an effective, accepted, and front-line therapy against cancer. In this review, we will provide a brief overview of BNCT, and its potential and challenges, and we will discuss the most promising strategies that have been developed so far.

Graphical abstract: Polymers and boron neutron capture therapy (BNCT): a potent combination

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Article information


Submitted
30 Sep 2020
Accepted
08 Feb 2021
First published
23 Mar 2021

This article is Open Access

Polym. Chem., 2021,12, 2035-2044
Article type
Review Article

Polymers and boron neutron capture therapy (BNCT): a potent combination

A. Pitto-Barry, Polym. Chem., 2021, 12, 2035
DOI: 10.1039/D0PY01392G

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