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Issue 25, 2021

Iminosugars as glycosyltransferase inhibitors

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Abstract

Iminosugars are naturally occurring carbohydrate analogues known since 1967. These natural compounds and hundreds of their synthetic derivatives prepared over five decades have been mainly exploited to inhibit the glycosidases, the enzymes catalysing the glycosidic bond cleavage, in order to find new drugs for the treatment of type 2 diabetes and other diseases. However, iminosugars are also inhibitors of glycosyltransferases, the enzymes responsible for the synthesis of oligosaccharides and glycoconjugates. The selective inhibition of specific glycosyltransferases involved in cancer or bacterial infections could lead to innovative therapeutic agents. The synthesis and biological properties of all the iminosugars assayed to date as glycosyltransferase inhibitors are reviewed in the present article.

Graphical abstract: Iminosugars as glycosyltransferase inhibitors

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Article information


Submitted
27 Feb 2021
Accepted
13 Apr 2021
First published
21 Apr 2021

Org. Biomol. Chem., 2021,19, 5439-5475
Article type
Review Article

Iminosugars as glycosyltransferase inhibitors

I. Conforti and A. Marra, Org. Biomol. Chem., 2021, 19, 5439 DOI: 10.1039/D1OB00382H

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