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Facile room-temperature self-assembly of extended cation-free guanine-quartet network on Mo-doped Au(111) surface

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Abstract

Guanine-quadruplex, consisting of several stacked guanine-quartets (GQs), has emerged as an important category of novel molecular targets with applications from nanoelectronic devices to anticancer drugs. Incorporation of metal cations into a GQ structure is utilized to form stable G-quadruplexes, while formation of a cation-free GQ network has been challenging. Here we report the room temperature (RT) molecular self-assembly of extended pristine GQ networks on an Au(111) surface. An implanted molybdenum atom within the Au(111) surface is used to nucleate and stabilize the cation-free GQ network. Additionally, decoration of the Au(111) surface with 7-armchair graphene nanoribbons (7-AGNRs) enhances the GQ domain size by suppressing the influence of the disordered phase nucleated from Au step edges. Scanning tunneling microscopy/spectroscopy (STM/STS) and density functional theory (DFT) calculations confirm the formation of GQ networks and unravel the nucleation and growth mechanism. Our work, utilizing a hetero-atom doped substrate, provides a facile approach to enhance the stability and domain size of the GQ self-assembly, which would be applicable for other molecular structures.

Graphical abstract: Facile room-temperature self-assembly of extended cation-free guanine-quartet network on Mo-doped Au(111) surface

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Article information


Submitted
30 Mar 2021
Accepted
05 May 2021
First published
20 May 2021

This article is Open Access

Nanoscale Adv., 2021, Advance Article
Article type
Paper

Facile room-temperature self-assembly of extended cation-free guanine-quartet network on Mo-doped Au(111) surface

A. Ghassami, E. Oleiki, D. Y. Kim, H. Shin, G. Lee and K. S. Kim, Nanoscale Adv., 2021, Advance Article , DOI: 10.1039/D1NA00235J

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