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Mechanisms and inhibitors of nicotinamide N-methyltransferase

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Abstract

Nicotinamide N-methyltransferase (NNMT) plays an important role in diverse biological processes by regulating methylation potential and the degradation of nicotinamide. Meanwhile, the aberrant expression of NNMT has been implicated in multiple cancers, metabolic and liver diseases. Therefore, there has been an emerging interest in assessing NNMT as a potential therapeutic target and discovering NNMT inhibitors over the past 5 years. Herein, we focus on the recognition, mechanism, and inhibitors of NNMT with emphasis on key advancements in the field. We also discuss future directions for the development of NNMT inhibitors.

Graphical abstract: Mechanisms and inhibitors of nicotinamide N-methyltransferase

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Article information


Submitted
17 Jan 2021
Accepted
22 Apr 2021
First published
19 May 2021

RSC Med. Chem., 2021, Advance Article
Article type
Review Article

Mechanisms and inhibitors of nicotinamide N-methyltransferase

I. D. Iyamu and R. Huang, RSC Med. Chem., 2021, Advance Article , DOI: 10.1039/D1MD00016K

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