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Issue 3, 2021
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An environmentally friendly wound dressing based on a self-healing, extensible and compressible antibacterial hydrogel

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Abstract

The design of wound dressing hydrogels is of utmost importance in healthcare with desired remedial effects, self-healing ability, cell affinity, and appropriate mechanical properties, particularly for healing skin wounds; excellent wound tissue adhesiveness is imperative. Here, an ultra-tough and self-healable double-network (DN) hydrogel is designed based on salep/poly(vinyl alcohol) that is endowed with superior tissue adhesiveness and cell affinity as demonstrated for critical and burn wound healing in rats. The self-healing capability of the hydrogel is attained via hydrogen bonds and Schiff-base cross-linking between oxidized salep (OSa) and ethylene diamine-modified salep (SaHEA) chains (OSEA network). The interaction of hydroxyl groups of the poly(vinyl alcohol) (PVA) network effectively facilitates to create a stable mechanical structure and endow self-healing ability. The ensuing novel hydrogel is endowed with excellent self-healing ability, high mechanical strength (Young's modulus of up to 14 kPa; high fracture energy of up to 90 kJ m−3; compressive stress of 400 kPa), good tissue adhesiveness (up to 48 N m−1 adhesive strength), and superior therapeutic properties (cell viability of A375 cells >80%; remarkable healing of >60% in 14 and >98% in 21 days). The macroscopic evaluation revealed healing >80% in 14 days and 100% in 21 days that is achieved by combining both networks in a single system along with Arnebia extract and Ag nanoparticles (Ag NPs) in green media. In vitro and in vivo tests affirmed that the PVA/OSEA DN hydrogel could be an excellent candidate for skin tissue regeneration in medical applications.

Graphical abstract: An environmentally friendly wound dressing based on a self-healing, extensible and compressible antibacterial hydrogel

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Article information


Submitted
07 Aug 2020
Accepted
20 Dec 2020
First published
27 Jan 2021

Green Chem., 2021,23, 1312-1329
Article type
Paper

An environmentally friendly wound dressing based on a self-healing, extensible and compressible antibacterial hydrogel

M. Tavakolizadeh, A. Pourjavadi, M. Ansari, H. Tebyanian, S. J. Seyyed Tabaei, M. Atarod, N. Rabiee, M. Bagherzadeh and R. S. Varma, Green Chem., 2021, 23, 1312 DOI: 10.1039/D0GC02719G

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