Issue 14, 2021

Recent trends in biocatalysis


Biocatalysis has undergone revolutionary progress in the past century. Benefited by the integration of multidisciplinary technologies, natural enzymatic reactions are constantly being explored. Protein engineering gives birth to robust biocatalysts that are widely used in industrial production. These research achievements have gradually constructed a network containing natural enzymatic synthesis pathways and artificially designed enzymatic cascades. Nowadays, the development of artificial intelligence, automation, and ultra-high-throughput technology provides infinite possibilities for the discovery of novel enzymes, enzymatic mechanisms and enzymatic cascades, and gradually complements the lack of remaining key steps in the pathway design of enzymatic total synthesis. Therefore, the research of biocatalysis is gradually moving towards the era of novel technology integration, intelligent manufacturing and enzymatic total synthesis.

Graphical abstract: Recent trends in biocatalysis

Article information

Article type
Review Article
19 Dec 2020
First published
18 Jun 2021
This article is Open Access
Creative Commons BY-NC license

Chem. Soc. Rev., 2021,50, 8003-8049

Recent trends in biocatalysis

D. Yi, T. Bayer, C. P. S. Badenhorst, S. Wu, M. Doerr, M. Höhne and U. T. Bornscheuer, Chem. Soc. Rev., 2021, 50, 8003 DOI: 10.1039/D0CS01575J

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