Issue 93, 2021

Fe-Catalyzed dicarbofunctionalization of electron-rich alkenes with Grignard reagents and (fluoro)alkyl halides

Abstract

An iron-catalyzed regioselective dicarbofunctionalization of electron-rich alkenes is described. In particular, aryl- and alkyl vinyl ethers are used as effective linchpins to couple alkyl or (fluoro)alkyl halides and sp2-hybridized Grignard nucleophiles. Preliminary results demonstrate the ability to engage thioethers as linchpins and control enantioselectivity in these transformations, an area which is largely unexplored in iron-catalyzed three-component cross-coupling reactions.

Graphical abstract: Fe-Catalyzed dicarbofunctionalization of electron-rich alkenes with Grignard reagents and (fluoro)alkyl halides

Supplementary files

Article information

Article type
Communication
Submitted
19 Aug 2021
Accepted
26 Oct 2021
First published
09 Nov 2021

Chem. Commun., 2021,57, 12508-12511

Fe-Catalyzed dicarbofunctionalization of electron-rich alkenes with Grignard reagents and (fluoro)alkyl halides

M. E. Rotella, D. Sar, L. Liu and O. Gutierrez, Chem. Commun., 2021, 57, 12508 DOI: 10.1039/D1CC04619E

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