Recent advances in transition metal-catalyzed (1,n) annulation using (de)-hydrogenative coupling with alcohols

Abstract

(1,n) annulation reactions using (de)-hydrogenative coupling with alcohols or diols represent a straightforward technique for the synthesis of cyclic moieties. Utilization of such renewable resources for chemical transformations in a one-pot manner is the main focus, which avoids generation of stoichiometric waste. Application of such (1,n) annulation approaches drives the catalysis research in a more sustainable way and generates dihydrogen and water as by-products. This feature article highlights the recent (from 2015 to March 2021) progress in the synthesis of stereo-selective cycloalkanes and cycloalkenes, saturated and unsaturated N-heterocycles (cyclic amine, imide, lactam, tetrahydro β-carboline, quinazoline, quinazolinone, 1,3,5-triazines etc.) and other N-heterocycles with the formation of multiple bonds in a one pot operation. Mechanistic studies, new catalytic approaches, and synthetic applications including drug synthesis and post-drug derivatization, scope, and limitations are discussed.

Graphical abstract: Recent advances in transition metal-catalyzed (1,n) annulation using (de)-hydrogenative coupling with alcohols

Article information

Article type
Feature Article
Submitted
25 Jun 2021
Accepted
06 Aug 2021
First published
06 Aug 2021

Chem. Commun., 2021, Advance Article

Recent advances in transition metal-catalyzed (1,n) annulation using (de)-hydrogenative coupling with alcohols

S. Bera, L. M. Kabadwal and D. Banerjee, Chem. Commun., 2021, Advance Article , DOI: 10.1039/D1CC03404A

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