Immune evasion of SARS-CoV-2 variants of concern is driven by low affinity to neutralizing antibodies†
Matheus V. F.
Ferraz, 
‡ab
Emerson G.
Moreira,
‡ab
Danilo F.
Coêlho,
‡ab
Gabriel L.
Wallau
‡a
and
Roberto D.
Lins
‡*a
‡ab
Emerson G.
Moreira,
‡ab
Danilo F.
Coêlho,
‡ab
Gabriel L.
Wallau
‡a
and
Roberto D.
Lins
‡*a
Abstract
SARS-CoV-2 VOC immune evasion is mainly due to lower cross-reactivity from previously elicited class I/II neutralizing antibodies, while increased affinity to hACE2 plays a minor role. The affinity between antibodies and VOCs is impacted by remodeling of the electrostatic surface potential of the Spike RBDs. The P.3 variant is a putative VOC.
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