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Issue 34, 2021
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Calcium-induced reversible assembly of phosphorylated amphiphile within lipid bilayer membranes

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Abstract

Inspired by calcium-induced reversible assembly and disassembly of membrane proteins found in nature, here we developed a phosphorylated amphiphile (PA) that contains an oligo(phenylene–ethynylene) unit as a hydrophobic unit and a phosphate ester group as a hydrophilic calcium-binding unit. We demonstrated that PA can assemble and disassemble in a reversible manner in response to the sequential addition of calcium chloride and ethylene-diaminetetraacetic acid within the lipid bilayer membranes for the first time as a synthetic molecule.

Graphical abstract: Calcium-induced reversible assembly of phosphorylated amphiphile within lipid bilayer membranes

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Article information


Submitted
28 Feb 2021
Accepted
31 Mar 2021
First published
01 Apr 2021

Chem. Commun., 2021,57, 4106-4109
Article type
Communication

Calcium-induced reversible assembly of phosphorylated amphiphile within lipid bilayer membranes

Y. Shimizu, K. Sato and K. Kinbara, Chem. Commun., 2021, 57, 4106
DOI: 10.1039/D1CC01111A

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