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Ultrasensitive detection of programmed death-ligand 1 (PD-L1) in whole blood using dispersible electrodes

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Abstract

The direct quantification of programmed death-ligand 1 (PD-L1) as a biomarker for cancer diagnosis, prognosis and treatment efficacy is an unmet clinical need. Herein, we demonstrate the first report of rapid, ultrasensitive and selective electrochemical detection of PD-L1 directly in undiluted whole blood using modified gold-coated magnetic nanoparticles as “dispersible electrodes” with an ultralow detection limit of 15 attomolar and a response time of only 15 minutes.

Graphical abstract: Ultrasensitive detection of programmed death-ligand 1 (PD-L1) in whole blood using dispersible electrodes

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Article information


Submitted
12 Dec 2020
Accepted
02 Feb 2021
First published
04 Feb 2021

Chem. Commun., 2021, Advance Article
Article type
Communication

Ultrasensitive detection of programmed death-ligand 1 (PD-L1) in whole blood using dispersible electrodes

P. Moazzam, M. Myekhlai, A. Alinezhad, F. A. Alshawawreh, P. Bakthavathsalam, V. R. Gonçales, R. D. Tilley and J. J. Gooding, Chem. Commun., 2021, Advance Article , DOI: 10.1039/D0CC08068C

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