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Issue 12, 2021
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Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors

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Abstract

The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some β-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.

Graphical abstract: Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors

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Supplementary files

Article information


Submitted
14 Oct 2020
Accepted
23 Nov 2020
First published
19 Jan 2021

This article is Open Access

Chem. Commun., 2021,57, 1430-1433
Article type
Communication

Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors

T. R. Malla, A. Tumber, T. John, L. Brewitz, C. Strain-Damerell, C. D. Owen, P. Lukacik, H. T. H. Chan, P. Maheswaran, E. Salah, F. Duarte, H. Yang, Z. Rao, M. A. Walsh and C. J. Schofield, Chem. Commun., 2021, 57, 1430
DOI: 10.1039/D0CC06870E

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