Issue 14, 2021
From the journal:

Chemical Communications

Magnetic resonance thermometry using a GdIII-based contrast agent†

S. A. Amali S. Subasinghe, ORCID logo a   Jonathan Romero,b   Cassandra L. Ward,c   Matthew D. Bailey,a   Donna R. Zehner,b   Prakrut J. Mehta,b   Fabio Carniato, ORCID logo d   Mauro Botta, ORCID logo d   Jason T. Yustein,e   Robia G. Pautlerb  and  Matthew J. Allen ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA
E-mail: mallen@chem.wayne.edu

b Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA

c Lumigen Instrument Center, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA

d Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “Amedeo Avogadro”, Viale T. Michel 11, Alessandria 15121, Italy

e Integrative Molecular and Biomedical Sciences and the Department of Pediatrics in the Texas Children's Cancer and Hematology Centers and The Faris D. Virani Ewing Sarcoma Center, Baylor College of Medicine, Houston, Texas 77030, USA

Abstract

The complexes described here serve as contrast agents for magnetic resonance imaging thermometry. The complexes differentially enhance contrast between 275 and 325 K. The basis of the temperature response of the fluorinated contrast complex is the modulation of water exchange caused by trifluoromethyl groups that can be chemically controlled.

Graphical abstract: Magnetic resonance thermometry using a GdIII-based contrast agent

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Article information

DOI
https://doi.org/10.1039/D0CC06400A
Article type
Communication
Submitted
24 Sep 2020
Accepted
09 Jan 2021
First published
21 Jan 2021

Chem. Commun., 2021,57, 1770-1773

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Magnetic resonance thermometry using a GdIII-based contrast agent

S. A. A. S. Subasinghe, J. Romero, C. L. Ward, M. D. Bailey, D. R. Zehner, P. J. Mehta, F. Carniato, M. Botta, J. T. Yustein, R. G. Pautler and M. J. Allen, Chem. Commun., 2021, 57, 1770 DOI: 10.1039/D0CC06400A

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