Issue 5, 2021

Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)

Abstract

A simple-to-implement and experimentally validated computational workflow for sequence modification of peptide inhibitors of protein–protein interactions (PPIs) is described.

Graphical abstract: Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)

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Article information

Article type
Communication
Submitted
26 Jun 2021
Accepted
30 Jul 2021
First published
16 Aug 2021
This article is Open Access
Creative Commons BY license

RSC Chem. Biol., 2021,2, 1474-1478

Towards optimizing peptide-based inhibitors of protein–protein interactions: predictive saturation variation scanning (PreSaVS)

K. Hetherington, S. Dutt, A. A. Ibarra, E. E. Cawood, F. Hobor, D. N. Woolfson, T. A. Edwards, A. Nelson, R. B. Sessions and A. J. Wilson, RSC Chem. Biol., 2021, 2, 1474 DOI: 10.1039/D1CB00137J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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