Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Dual-triggered nanoaggregates of cucurbit[7]uril and gold nanoparticles for multi-spectroscopic quantification of creatinine in urinalysis

Author affiliations

Abstract

Plasmonic nanocomposites of cucurbit[7]uril (CB7) and gold nanoparticles (Au NPs) have been optimised and applied to rapidly detect and quantify creatinine (CRN) of clinically relevant levels in urinalysis. The in situ formation of plasmonic nanocomposites via aqueous self-assembly is mediated by a combination of the portal binding of CB7 and the electrostatic effects of CRN molecules, allowing independent spectral signatures to be extracted from the same sample solution using surface-enhanced Raman spectroscopy (SERS) and UV-Visible spectroscopy. Meanwhile the formation of host–guest complexes between CB7 and CRN allows quantification of CRN in highly diluted synthetic urine by localising CRN at or in close proximity to the plasmonic hotspots within the Au NP:CB7 nanoaggregates, which enables highly reproducible SERS signals (within 5% error) with a sub-μM detection limit of 12.5 ng mL−1 (111 nM) and has tolerance against the presence of proteins and other biomolecules in a complex matrix. Our nanobiosensing material platform demonstrates the potential to be extended to other in-field applications.

Graphical abstract: Dual-triggered nanoaggregates of cucurbit[7]uril and gold nanoparticles for multi-spectroscopic quantification of creatinine in urinalysis

Back to tab navigation

Supplementary files

Article information


Submitted
22 Feb 2020
Accepted
07 Apr 2020
First published
07 Apr 2020

This article is Open Access

J. Mater. Chem. C, 2020, Advance Article
Article type
Paper

Dual-triggered nanoaggregates of cucurbit[7]uril and gold nanoparticles for multi-spectroscopic quantification of creatinine in urinalysis

W. K. Chio, S. Moorthy, J. Perumal, D. U. S., I. P. Parkin, M. Olivo and T. Lee, J. Mater. Chem. C, 2020, Advance Article , DOI: 10.1039/D0TC00931H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements