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Ratiometric fluorescence detection of anthrax biomarker 2,6-dipicolinic acid using hetero MOF sensors through ligand regulation

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Abstract

2,6-Dipicolinic acid (DPA) is an anthrax biomarker, whose detection is in great need. This work presented nine MOFs of three series containing three ligands of 2,6-naphthalene-dicarboxylic acid (H2NDC), 4,4′-biphenyldicarboxylic acid (H2BPDC), and 1,4-benzenedicarboxylate acid (H2BDC): six single Ln-MOFs (Ln = Eu3+ (1, 4 and 7) and Tb3+ (2, 5 and 8)) and three hetero Eu/Tb-MOFs (3, 6, and 9). This work aimed at ligand regulation of the fluorescence properties and DPA detection. The solid-state emissions of 3, 6, and 9 can be assigned to the characteristic transitions of Eu3+ (5D07FJ (J = 1–4)) and/or Tb3+ (5D47FJ (J = 6–3)). The hetero MOFs were applied as fluorescence sensors in DPA detection. The fluorescence and DPA detection performances of 3, 6 and 9 are related to the energy differences between the ligands/DPA and Ln3+, showing the effect of ligand energy regulation and the competition between the three ligands and DPA. The detection performances of 3, 6 and 9 show linear responses of ITb/IEu vs. DPA concentration with the limit of detections of 0.248 μM (3), 0.874 μM (6), and 2.277 μM (9). Seven interferents did not affect the DPA detection using 3, 6 and 9. Time-dependent fluorescence measurement suggested that 3, 6 and 9 responded very fast to DPA. High recoveries in the DPA detection of 3, 6 and 9 in human serum (93.96 to 108.84%) indicated their high reliabilities. The paper-based MOF sensors of 3, 6 and 9 could display emission color changes depending on CDPA, which offers a fast field detection method for DPA.

Graphical abstract: Ratiometric fluorescence detection of anthrax biomarker 2,6-dipicolinic acid using hetero MOF sensors through ligand regulation

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Supplementary files

Article information


Submitted
20 Jan 2020
Accepted
18 Feb 2020
First published
20 Feb 2020

J. Mater. Chem. C, 2020, Advance Article
Article type
Paper

Ratiometric fluorescence detection of anthrax biomarker 2,6-dipicolinic acid using hetero MOF sensors through ligand regulation

M. Shen, B. Liu, L. Xu and H. Jiao, J. Mater. Chem. C, 2020, Advance Article , DOI: 10.1039/D0TC00364F

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