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Dual Eu-MOFs based logic device and ratiometric fluorescence paper microchip for visual H2O2 assay

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Abstract

Hydrogen peroxide (H2O2) is a typical reactive peroxide that is widely used in food preservation but may cause serious harm to human health. Thus, a simple, efficient and accurate method for H2O2 assay is essential. In this work, a dual Eu-MOFs-based ratiometric fluorescence sensor, a logic gate-based advanced analytical method, and a dual MOFs-loaded paper microchip for visual H2O2 assay were constructed. The H2O2 sensor was response-sensitive (limit of detection: 0.14 μM) and linearly responsive in the concentration range of 0.001–1 mM (r > 0.99). Then, an advanced AND gate logic device was established to monitor H2O2 concentration. Moreover, the paper-based microchip realized the point-of-care visual H2O2 assay via ratiometric chromaticity assisted by a portable smartphone-based visual assay device. The microchip consumes only 5 μL of sample and demonstrates long-term stability for over 30 days along with response-sensitivity. Both the MOF dispersion-based ratiometric fluorescence sensor and the paper microchip realized an accurate and precise assay of H2O2 (the recovery was 88.2–105.5% and RSD < 9.3%). To the best of our knowledge, this is the first report of a dual MOFs-based ratiometric fluorescent H2O2 sensor, an advanced logic gate-based analytical method, and a paper-based microchip for visual point-of-care H2O2 assay.

Graphical abstract: Dual Eu-MOFs based logic device and ratiometric fluorescence paper microchip for visual H2O2 assay

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Supplementary files

Article information


Submitted
18 Dec 2019
Accepted
23 Jan 2020
First published
07 Feb 2020

J. Mater. Chem. C, 2020, Advance Article
Article type
Paper

Dual Eu-MOFs based logic device and ratiometric fluorescence paper microchip for visual H2O2 assay

L. Yu, C. He, Q. Zheng, L. Feng, L. Xiong and Y. Xiao, J. Mater. Chem. C, 2020, Advance Article , DOI: 10.1039/C9TC06915A

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