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Aggregation-Induced Phosphorescent Emission-Active Ir(III) Complexes with Long Lifetime for Specific Mitochondrial Imaging and Tracking

Abstract

Ir(III) complexes have been widely used in bio-imaging, photocatalysis and chemical sensing. Five cyclometalated Ir(III) complexes (Ir1–Ir5) were synthesized and characterized. Among them, Ir2, Ir3 and Ir4 can exhibit high luminescence efficiency and relatively long phosphorescence lifetimes. Ir2, Ir3 and Ir4 are suitable for imaging and tracking of mitochondrial due to better photostability and luminescence quantum yields than commercially available mitochondrial trackers. Ir2, Ir3 and Ir4 displayed significant aggregation-induced emission behaviors from restricted intramolecular motion. Confocal microscopy showed that these complexes accumulate selectively in mitochondria. In cell cytotoxicity investigations revealed that Ir(III) complexes showed a negligible cytotoxicity at the concentrations used. Our study provides insight into the relationship between the structure and the physical properties. These results indicate that these Ir(III) complexes are suitable for mitochondrial imaging in living cells.

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Supplementary files

Article information


Submitted
19 Oct 2019
Accepted
30 Dec 2019
First published
02 Jan 2020

J. Mater. Chem. C, 2020, Accepted Manuscript
Article type
Paper

Aggregation-Induced Phosphorescent Emission-Active Ir(III) Complexes with Long Lifetime for Specific Mitochondrial Imaging and Tracking

Y. Li, B. Ma, Y. Long, J. Su, Y. Wang, Z. Song, R. Liu, G. Song and H. Zhu, J. Mater. Chem. C, 2020, Accepted Manuscript , DOI: 10.1039/C9TC05724B

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