Jump to main content
Jump to site search


Synthesis of heteronanostructures for multimodality molecular imaging-guided photothermal therapy

Author affiliations

Abstract

Combining photothermal therapy (PTT) and multimodality molecular imaging into one nanotheranostic can improve the diagnostics and therapeutics outcome of malignant tumors significantly. Herein, a heteronanostructure (named Au-Fe3O4@PDA-PEG-DTPA-Gd) has been synthesized for multimodality molecular imaging-guided PTT by conjugation of gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) on a polydopamine (PDA) coated Au-Fe3O4 heterodimeric via a polyethylene glycol (PEG) crosslinker. Au-Fe3O4@PDA-PEG-DTPA-Gd exhibits reasonable biocompatibility, high photothermal conversion efficiency (η = 41.3%), integration of excellent T1-/T2-weighted magnetic resonance imaging (MRI, the molar longitudinal relaxivity rate (r1) = 6.14 mM−1 s−1/transverse relaxation rate (r2) = 71.88 mM−1 s−1) and X-ray computed tomography imaging (CT, approximately 1.94 times higher than that of the commercial CT contrast agent ioversol) contrast functionality. The theranostic capability of Au-Fe3O4@PDA-PEG-DTPA-Gd has been verified on the triple negative breast tumor cell (MDA-MB-231 cell) and MDA-MB-231 tumor-bearing mouse model. From MR/CT imaging, Au-Fe3O4@PDA-PEG-DTPA-Gd shows remarkable PTT efficacy, which completely inhibits MDA-MB-231 tumor growth in vivo with a single treatment.

Graphical abstract: Synthesis of heteronanostructures for multimodality molecular imaging-guided photothermal therapy

Back to tab navigation

Supplementary files

Article information


Submitted
03 Sep 2020
Accepted
27 Sep 2020
First published
29 Sep 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

Synthesis of heteronanostructures for multimodality molecular imaging-guided photothermal therapy

F. Xu, X. Li, H. Chen, M. Jian, Y. Sun, G. Liu, L. Ma and Z. Wang, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB02136A

Social activity

Search articles by author

Spotlight

Advertisements