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Issue 40, 2020
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A rapid response near-infrared ratiometric fluorescent probe for the real-time tracking of peroxynitrite for pathological diagnosis and therapeutic assessment in a rheumatoid arthritis model

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Abstract

Peroxynitrite (ONOO) is a potent bio-oxidant involved in many physiological and pathological processes; however, most of the pathological effects associated with ONOOin vivo are still ambiguous. Herein, we designed and synthesized two near-infrared ratiometric fluorescent probes, Ratio-A and Ratio-B, for the detection and biological evaluation of ONOO. The recognition unit diene in the probes could be specifically cleaved by ONOO with a 94-fold enhancement in the ratiometric fluorescence signal. By imaging ONOO in immune stimulated cells and acute inflammation mice model using Ratio-A, we investigated the fluctuations of ONOO levels in a rheumatoid arthritis (RA) model of mice. Ratio-A could be applied for the effective imaging of RA and could rapidly evaluate the response of the RA treatment with methotrexate (MTX). Thus, Ratio-A can be considered as a promising tool for pathological diagnosis and the therapeutic assessment of a wide range of diseases including RA.

Graphical abstract: A rapid response near-infrared ratiometric fluorescent probe for the real-time tracking of peroxynitrite for pathological diagnosis and therapeutic assessment in a rheumatoid arthritis model

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Supplementary files

Article information


Submitted
14 Aug 2020
Accepted
08 Sep 2020
First published
12 Sep 2020

J. Mater. Chem. B, 2020,8, 9343-9350
Article type
Paper

A rapid response near-infrared ratiometric fluorescent probe for the real-time tracking of peroxynitrite for pathological diagnosis and therapeutic assessment in a rheumatoid arthritis model

J. Lu, Z. Li, X. Zheng, J. Tan, Z. Ji, Z. Sun and J. You, J. Mater. Chem. B, 2020, 8, 9343
DOI: 10.1039/D0TB01970D

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