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Extracellular matrix coating improves the biocompatibility of polymeric heart valves

Abstract

Prosthetic heart valve replacement is an effective therapy for patients with valvular heart disease. New-type polymer materials provide potential choices of material for preparing prosthetic heart valves. In this study, we focused on enhancing the biocompatibility of polystyrene-block-isobutylene-block-styrene (SIBS) by surface modification with an extracellular matrix (ECM). Experimental results demonstrated that the ECM coating increased the adsorption resistance against protein and platelet. SIBS coated with ECM adsorbed much less bovine serum albumin and fibrinogen (5.38 ug/cm2 and 31.53 ug/cm2 , respectively) than the original material (90.84 ug/cm2 and 132.38 ug/cm2, respectively). The relative platelet adsorption of the ECM-modified SIBS was lower than that of SIBS (0.04 versus 0.10). Moreover, the surface coating could also reduce endothelial cytotoxicity, suppress the immune response, and potentially induce tissue regeneration. In conclusion, the ECM coating improved the biocompatibility of SIBS effectively.

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Article information


Submitted
04 Aug 2020
Accepted
13 Oct 2020
First published
13 Oct 2020

J. Mater. Chem. B, 2020, Accepted Manuscript
Article type
Paper

Extracellular matrix coating improves the biocompatibility of polymeric heart valves

B. Wu, L. Jin, K. Ding, Y. Zhou, L. Yang, Y. Lei, Y. Guo and Y. Wang, J. Mater. Chem. B, 2020, Accepted Manuscript , DOI: 10.1039/D0TB01884H

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