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A nanoplatform based on mesoporous silica-coated gold nanorods for cancer triplex therapy

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Abstract

To enhance the efficacy of nanoparticle-based cancer therapy with reduced side effects and promote its clinical translation, a biocompatible nanocomposite based on mesoporous silica-coated gold nanorods (AuNR@MSN) for triple tumor therapy is reported in this study. The gold core served as a hyperthermia agent, while the MSN shell acted as a reservoir of chemotherapeutics owing to its excellent loading capacity. Cytochrome c with the apoptosis inducing function was anchored on the surface of AuNR@MSN to prevent drug leakage through redox-responsive disulfide bonds. The successful construction of a nanocomposite was confirmed by characterization of the physicochemical properties. In vitro and in vivo studies demonstrated that the nanocomposite displayed an optimizing anti-tumor effect with a synergistic strategy of excellent photothermal therapy, chemotherapy and protein therapy. Therefore, this cooperative strategy paves the way for high-efficiency oncotherapy with reduced side effects.

Graphical abstract: A nanoplatform based on mesoporous silica-coated gold nanorods for cancer triplex therapy

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Article information


Submitted
10 Jul 2020
Accepted
07 Sep 2020
First published
16 Sep 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

A nanoplatform based on mesoporous silica-coated gold nanorods for cancer triplex therapy

G. Liu, H. Liang, Y. He, L. Lu, L. Wang, P. Liu and K. Cai, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB01707H

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